[ Title ]
- FOXP3 autoantibody as a potential early prognostic serum biomarker in
patients with cervical cancer
[ Journal ]
- INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
[ Author ]
- Xu, S
Huangfu, MM
Jia, XL
Song, XW
Sun, BS
Lee, KH
Liu, LL
Sun, SL
[ Abstract ]
- Overexpression of tumor-associated antigens has been reported in many
types of cancer and may trigger secretion of their autoantibodies. The
present work was designed to test whether circulating antibody to FOXP3
protein-derived antigens was altered in early cervical cancer and
cervical benign tumors.
A total of 141 patients with cervical cancer, 133 patients with cervical
benign tumors and 148 healthy age-matched volunteers were recruited. The
level of circulating anti-FOXP3 IgG antibody was tested using an
enzyme-linked immunosorbent assay developed in-house with linear peptide
antigens derived from FOXP3 protein. The linear peptide antigens were
designed according to the computational prediction of HLA-II epitopes.
Student's t test showed that anti-FOXP3 IgG in the malignant tumor group
and the benign tumor group was significantly higher than in the control
group (t = 6.127, p < 0.001; t = 2.704, p = 0.007). In addition,
patients with stage I cervical cancer (t = 2.968, p = 0.003) had a
significantly higher level of FOXP3 autoantibodies than patients with
benign tumors. The sensitivity against > 90 % specificity was 20.6 %
with an interassay deviation of 11.7 % in the cervical cancer group.
Based on a cut-off value determined by the 98th percentile of the
control group IgG levels, the anti-FOXP3 IgG positivity was 2.1 % in
patients with cervical cancer compared to 2.0 % in the health controls
(chi-squared = 0.004, p = 0.952, OR = 1.051, 95 % CI 0.209-5.295).
The circulating autoantibody to FOXP3 reflecting the continuous
development of the cervical lesion, may be a potential biomarker with
early prognostic values for cervical cancer.
[ URL ]
- http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS&DestLinkType=FullRecord;UT=WOS:000362002200019