[ Title ]
- Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies
[ Journal ]
- Nature Medicine
[ Author ]
- D. C. Lipson, M.Yelensky, R.Otto, G.Parker, A.Jarosz, M.Curran, J. A.Balasubramanian, S.Bloom, T.Brennan, K. W.Donahue, A.Downing, S. R.Frampton, G. M.Garcia, L.Juhn, F.Mitchell, K. C.White, E.White, J.Zwirko, Z.Peretz, T.Nechushtan, H.Soussan-Gutman, L.Kim, J.Sasaki, H.Kim, H. R.Park, S. I.Ercan, D.Sheehan, C. E.Ross, J. S.Cronin, M. T.Janne, P. A.Stephens, P. J.
[ Abstract ]
- Applying a next-generation sequencing assay targeting 145 cancer-relevant genes in 40 colorectal cancer and 24 non-small cell lung cancer formalin-fixed paraffin-embedded tissue specimens identified at least one clinically relevant genomic alteration in 59% of the samples and revealed two gene fusions, C2orf44-ALK in a colorectal cancer sample and KIF5B-RET in a lung adenocarcinoma. Further screening of 561 lung adenocarcinomas identified 11 additional tumors with KIF5B-RET gene fusions (2.0%; 95% CI 0.8-3.1%). Cells expressing oncogenic KIF5B-RET are sensitive to multi-kinase inhibitors that inhibit RET.
[ URL ]
- ://WOS:000301264800038